The scientifically substantiated art of teaching. The case for neuroscience in the art of teaching -- Using what we know as fact -- Considering what to do with what is probably true -- Evaluating the usage of what is still just intelligent speculation -- Weeding out neuromyths and misunderstandings -- Applying mind, brain, education science in the classroom. Tenets: applying knowledge about the individual nature of learning to classroom teaching -- Principles: applying universal concepts about the brain and learning to classroom teaching -- Ten instructional guidelines in MBE science -- How do we distinguish good information from bad in MBE science? -- Improving the field and moving forward.