Wickett's Remedy leads us back to Boston in the early part of the 20th century and into the world of Lydia, an Irish-American shop girl yearning for a grander world than the cramped confines of South Boston. She seems to be well on her way to the life she has dreamed of when she marries Henry Wickett, a shy medical student and the scion of a Boston Brahmin family. Soon after their wedding, however, Henry shocks Lydia by quitting medical school and creating a mail-order patent medicine called Wickett's Remedy. And then just as the enterprise is getting off the ground, the Spanish Influenza epidemic of 1918 begins its deadly sweep across the world, drastically changing their lives.