Jessica Flem has spent most of her life reacting allergically to everything — even when she’s acing her favourite video game. She’s used to a nose that never stops running, but is not at all prepared for the mysterious power that shows up around her thirteenth birthday — the ability to transform her mucus-filled tissues into slimy magical helpers! And just in time, too. It turns out there are forces both good and evil who have had their eyes on her and three other “special” kids since their exposure at birth to a mysterious element called reidium. Jess must draw on her full video game knowledge to face the evil Boss’s quest for world domination. The stakes mount higher and higher, but with her best friend Cliff at her side and her arsenal of mighty... um, tissues, Jess is determined to make Dimly a safe place once again.

Each book in the series begins with a 7 page comic strip that explains the characters' common origin story.