As the Fantastic Four embark on a strange mission, they aren't met with new beginnings, but an untimely end! Marvel's first family heads towards their darkest hour, but who is behind their downfall? Manhattan is under attack by a killer swarm from a corrupted pocket universe, and in order to defeat it, the Human Torch must make a terrible sacrifice! And with one member down, a new menace emerges: the Wrecking Crew, their powers mysteriously elevated! As Ben and Alicia's romance rekindles, the threats of Fin Fang Foom, the Wizard and the Puppet Master loom, the Baxter Building is quarantined, and the Fantastic Four are held accountable for the destruction in Manhattan! It's the trial of the century, and a major turning point for the family!

Title from indicia. Contains material originally published in magazine form as Fantastic Four #1-5.