Steve Rogers' reality has been secretly rewritten by the sentient Cosmic Cube named Kobik, who was acting under the influence of the Red Skull. Now, because a Hydra agent named Elisa Sinclair saw Steve's potential and recruited him as a young boy. Captain America is now determined to save the world by expanding Hydra's influence, but a major obstacle has appeared in his way: a new Inhuman who can see the future threatens to expose Steve's secret at any moment, and has predicted Steve's death at the hands of the younger Spider-Man, Miles Morales.

Variant cover title: The defenders.