Gregory, a straight-jacketed child, is eternally trapped in a barren holding cell where he spends his time in drooling vegetation, banging his head on walls or shouting nonsensical, monosyllabic words. The only thing Gregory can communicate is his own name, which he enjoys screaming to the consternation of medical staff, therapists and asylum outsiders. This is a collection of low-brow humor based on Gregory's misadventures in confinement, a cartoonish, hyperbolic story presented in Hempel's casual, sketchy style. .

Cover title. Volume 1 originally published in single magazine form as Gregory and Gregory II. Volume 1 originally published in single magazine form as Gregory III and Gregory IV: Fat boy.