"Reed Richards hunts for a cure to his molecular degeneration before it kills him and everyone he loves! Racing against time, he leads his family into the past on an adventure into the timestream as he searches for answers. They encounter an alien world where a thousand-year-old prophecy declares the Invisible Woman the world's long-awaited intergalactic messiah. Then, the F4 travel back to ancient Rome and dine with Caesar on the Ides of March before venturing to the literal dawn of time to witness the Big Bang. Once they've seen how everything begins, they see how it ends at the Big Crunch! Beyond even the limits of infinite time and space can Reed find the cure?" -- Back cover.

"Contains material originally published in single magazine form as Fantastic Four #4-8 and #5AU." "The world's greatest comic magazine!"