Follows the adventures of Ogami Itto, a samurai framed and forced into exile with his infant son, as he pursues his quest for revenge against those who murdered his wife.

Volume 1: Volume 1: The assassin's road, Lone Wolf and Cub volume 2: The gateless barrier, and Lone Wolf and Cub volume 3: The flute of the fallen tiger. Volume 2: Volume 3: The flute of the fallen tiger, Lone Wolf and Cub volume 4: The Bell Warden, and Lone Wolf and Cub volume 5: Black wind. Volume 3: Volume 5: Black wind; Lone Wolf and Cub volume 6: Lanterns for the dead; Lone Wolf and Cub volume 7: Cloud Dragon, Wind Tiger; and Lone Wolf and Cub volume 8: Chains of death. Volume 4: Volume 8: Chains of death; Lone Wolf and Cub Volume 9: Echo of the assassin; and Lone Wolf and Cub volume 10: Hostage child. Volume 5: Volume 10: Hostage child; Lone Wolf and Cub Volume 11: Talisman of Hades; and Lone Wolf and Cub volume 12: Shattered stones. Volume 6: Volume 13: The moon in the east, the sun in the west; Lone Wolf and Cub Volume 14: Day of the demons; and Lone Wolf and Cub volume 15: Brothers of the grass. Volume 7: Volume 15: Brothers of the grass; Lone Wolf and Cub Volume 16: Gateway into winter; and Lone Wolf and Cub volume 17: The will of the fang. Volume 8: Volume 17: The will of the fang; Lone Wolf and Cub Volume 18: Twilight of the Kurokuwa; and Lone Wolf and Cub volume 19: The moon in our hearts. Volume 9: Volume 19: The moon in our hearts; Lone Wolf and Cub Volume 20: A taste of poison; and Lone Wolf and Cub volume 21: Fragrance of death. Volume 10: Volume 21: Frangrance of death; Lone Wolf and Cub Volume 22: Heaven and earth; and Lone Wolf and Cub volume 23: Tears of ice; and Lone Wolf and Cub volume 24: In these small hands.