Isaac and Ivy Ramsey are the victims of the bet between two manufactured gods: the seductive and lethal Roxy (Oxycontin), and the smart, high-achieving Addison (Adderall). The wager: a contest to see who can bring their mark to a rave that has raged since the beginning of time. Drawn by what the drugs offer, tempted to take that step past helpful to harmful are Isaac, a soccer player thrown into Roxy's orbit by a bad fall; and Ivy, his sister, whose increasing frustration with her untreated ADHD leads her to renew her acquaintance with Addy. One will land on their feel; the other will be lost to the rave. The question is: which one?

Title on cover and title page have the R styled as the symbol for medical prescriptions.