A mix-up in the school science lab causes outgoing Kara (Supergirl) to swap personalities and powers with super-shy Karen (Bumblebee), and things start going topsy-turvy in no time. Now Wonder Woman and the other DC Super Hero Girls are going to have to help them switch back before the super-villains find out and cause even more trouble. Along the way, the super heroes learn to see things from other people's points of view.

First name of second illustrator is misspelled on title page. Correct spelling is Gabriella.