Creative Illustration is considered Loomis's magnum opus, which was aimed primarily at the professional-level illustrator. Divided into seven sections: Line, Tone, Color, Telling the Story, Creating Ideas, Fields of Illustration, and Experimenting and Studies, this book is filled with instructions, tips, insider experiences, and incredible illustrations.

Facsimile of the edition published: New York : Viking Press, 1947.

Line -- Tone -- Color -- Telling the story -- Creating ideas -- Fields of illustration -- Experiment and study.