"A mystery at Empire State University thrusts the webslinger into a thrilling adventure that starts in uptown Manhattan and takes him around the world--pitting Spidey against Marvel villains old and new and giving you a Spider-Man adventure (and a Spider-Man) the likes of which you've never seen! Something terrible is happening to ESU's students--some of New York's brightest young minds--and to save the day this time is going to take a side of Peter Parker that neither you nor Peter thought existed. And the clock is ticking!"--From publisher.

Includes: The new guard / Joe Kelly, writer ; Dale Eaglesham, artist. "Contains material originally published in single magazine form as Non-stop Spider-Man #1-5"--Copyright page.